Cell Cycle Phase Transitions: Signposts for Aberrant Cell Cycle Reentry in Dying Mature Neurons
نویسندگان
چکیده
منابع مشابه
Silencing Cell-Cycle Reentry in Postmitotic Neurons
Once neurons differentiate, cell-cycle proteins are downregulated, seemingly locking the cell in G0 phase. This suggests very tight control of expression of these proteins. However, increasing evidence suggests that cell-cycle proteins can be reactivated and contribute to cell demise. For example, the Cdk1– cyclin B1 complex can be reactivated in Alzheimer’s disease. The E3-ubiquitin ligase ana...
متن کاملE2F1 works as a cell cycle suppressor in mature neurons.
Neurons are highly differentiated cells that normally never enter a cell cycle; if they do, the result is usually death, not division. For example, cerebellar granule neurons in staggerer and lurcher mutant mice initiate a cell cycle-like process just before they die. E2F1 is a transcription factor that promotes cell cycle progression. Because E2F1 is also involved in apoptosis, we bred double ...
متن کاملA simple reentry into the cell cycle
A simple reentry into the cell cycle I t may be specialized, but a muscle cell is just a single step away from resuming division, as Pajalunga et al. reveal on page 807. The researchers show that removing one regulatory protein can push a range of nondividing cells back into the cell cycle. Most cells in adults aren't cycling. Some have slipped into quiescence, a temporary lull triggered by sca...
متن کاملAberrant cell cycle reentry in human and experimental inclusion body myositis and polymyositis.
Inclusion body myositis (IBM), a degenerative and inflammatory disorder of skeletal muscle, and Alzheimer's disease share protein derangements and attrition of postmitotic cells. Overexpression of cyclins and proliferating cell nuclear antigen (PCNA) and evidence for DNA replication is reported in Alzheimer's disease brain, possibly contributing to neuronal death. It is unknown whether aberrant...
متن کاملAberrant Cell Cycle Regulation in Cervical Carcinoma
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However, the time lag between HPV infection and the diagnosis of cancer indicates that multiple steps, as well as multiple factors, may be necessary for the development of cervical cancer. The ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cytology & Histology
سال: 2011
ISSN: 2157-7099
DOI: 10.4172/2157-7099.1000e101